melanoma in situ
Histologic Features
- A broad (>6 mm diameter), asymmetrical and poorly circumscribed proliferation of atypical melanocytes charactrized by
- Single cells and nests of larger melanocytes with hyperchromatic nucleoli and cytoplasm with dusty melanin
- Single cells predominating at some foci
- Pagetoid spread of single cells and nests
- Nests varying in size and shape
- Confluence of adjacent nests
- Marked solar elastosis of the papillary dermis
- Extension of cells down the adnexal epithelium
- Mitoses at some foci
- A band-like lymphocytic infiltrate at the base
- Focal fibrosis and pigment incontinence
Updated Wednesday, July 31, 2013 8:30:48 PM