extramammary Paget's disease
Histologic Features
- Compact orthokeratosis
- Slight epidermal hyperplasia
- A proliferation of Paget cells with large oval nuclei and abundant mucinous or granular cytoplasm as solitary units and aggregates scattered throughout the entire thickness of the epidermis
- Location of Paget cells basally and suprabasally, but not below the DE junction
- Presence of neoplastic cells within the adnexal structures
- An occasional signet-ring cell
- Occasional formation into acinar structures
- Prominent dermal vessels and a lichenoid infiltrate of lymphocytes and plasma cells
Updated Wednesday, July 31, 2013 8:30:48 PM